Major Trypanosoma cruzi antigenic determinant in Chagas' heart disease shares homology with the systemic lupus erythematosus ribosomal P protein epitope

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A Trypanosoma cruzi λgt11 cDNA clone, JL5, expressed a recombinant protein which was found to react predominantly with chronic Chagas' heart disease sera. The cloned 35-residue-long peptide was identified as the carboxyl-terminal portion of a T. cruzi ribosomal P protein. The JL5 13 carboxyl-te...

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Detalles Bibliográficos
Autores principales: Mesri, E.A., Levitus, G., Hontebeyrie-Joskowicz, M., Dighiero, G., Van Regenmortel, M.H.V., Levin, M.J.
Formato: JOUR
Materias:
epitope
recombinant protein
ribosome protein
synthetic peptide
adult
aged
amino acid sequence
antigen binding
article
chagas disease
clinical article
enzyme linked immunosorbent assay
heart disease
human
priority journal
protozoon
systemic lupus erythematosus
trypanosoma cruzi
Amino Acid Sequence
Animal
Antigens, Protozoan
beta-Galactosidase
Chagas Cardiomyopathy
Comparative Study
Enzyme-Linked Immunosorbent Assay
Epitopes
Human
Lupus Erythematosus, Systemic
Molecular Sequence Data
Phosphoproteins
Recombinant Proteins
Sequence Homology, Nucleic Acid
Support, Non-U.S. Gov't
Trypanosoma cruzi
Protozoa
Trypanosoma
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00951137_v28_n6_p1219_Mesri
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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