Synergism between baltergin metalloproteinase and Ba SPII RP4 PLA2 from Bothrops alternatus venom on skeletal muscle (C2C12) cells

Acute muscle damage, myonecrosis, is one of the main characteristics of envenoming by Bothrops genus. In this invitro study we investigated the role of a metalloproteinase (baltergin) and an acidic phospholipase A2 (Ba SPII RP4) in the cytotoxicity exhibited by Bothrops alternatus venom. Baltergin m...

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Detalles Bibliográficos
Autores principales: Bustillo, S., Gay, C.C., García Denegri, M.E., Ponce-Soto, L.A., Bal de Kier Joffé, E., Acosta, O., Leiva, L.C.
Formato: JOUR
Lenguaje:English
Materias:
Baltergin
Bothrops alternatus
C2C12
Cytotoxicity
Metalloproteinase
Phospholipase A2
Synergism
acidic phospholipase A2
baltergin
metalloproteinase
phospholipase A2
snake venom
unclassified drug
animal cell
anoikis
apoptosis
article
bothrops alternatus
controlled study
cytotoxicity
enzyme isolation
in vitro study
mouse
myoblast
nonhuman
poisonous snake
priority journal
protein function
Animals
Antibodies, Monoclonal
Bothrops
Cell Line
Crotalid Venoms
Drug Synergism
Metalloproteases
Mice
Mice, Inbred C3H
Muscle, Skeletal
Muscular Diseases
Phospholipases A2
Rabbits
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00410101_v59_n2_p338_Bustillo
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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