C(16)-C(22) oxygen-bridged analogues of ceDAF-12 and LXR ligands

The DAF-12 receptor in nematodes and the Liver X Receptor (LXR) in mammals are structurally related transcription factors that play key roles in determining the life span of the organism. Both types of receptors are activated by oxysterols, cholesterol metabolites with oxidized side chains. Restrict...

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Detalles Bibliográficos
Autores principales: Del Fueyo, M.C., Dansey, M.V., Paolo, L.S., Pecci, A., Veleiro, A.S., Burton, G.
Formato: JOUR
Materias:
DAF-12 receptor
Dafachronic acid
Liver X Receptor
Oxocarbenium reduction
Oxysterols
26 hydroxycholesterol
bacterial protein
cell nucleus receptor
DAF 12 receptor
DAF 12 receptor agonist
diosgenin
hormone receptor stimulating agent
liver X receptor
liver X receptor agonist
unclassified drug
cholestane derivative
cholesterol derivative
dafachronic acid
oxysterol
animal cell
Article
controlled study
desilylation
DNA binding
heteronuclear single quantum coherence
human
human cell
isomerization
ligand binding
mass spectrometry
nonhuman
nuclear magnetic resonance
oxidation
promoter region
protein conformation
reporter gene
stereochemistry
stereoisomerism
transactivation
transactivation assay
agonists
animal
cell line
chemical structure
chemistry
hamster
HEK293 cell line
metabolism
nuclear magnetic resonance spectroscopy
Animals
Cell Line
Cholestenes
Cricetinae
HEK293 Cells
Humans
Hydroxycholesterols
Liver X Receptors
Magnetic Resonance Spectroscopy
Molecular Structure
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_0039128X_v112_n_p109_DelFueyo
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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