The spontaneous motility and the prostaglandin E-like material generation is different in the implantation and in the non-implantation regions of the uterus isolated from rats in natural estrus. Influences of indomethacin

The spontaneous isometric developed tension (IDT) and the frequency of contractions (FC) of the implantation or linea uteri (LU) and the non implantation or myometrial region (M) from uterine horns in different stages of the sex cycle were studied. The functional activity (FA= IDT × FC) of LU and M...

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Detalles Bibliográficos
Autores principales: Gimeno, A.L., Borda, E.S., Peredo, H.A., Franchi, A.M., Lazzari, M.A., Gimeno, M.F.
Formato: JOUR
Materias:
indometacin
prostacyclin
prostaglandin
prostaglandin e2
prostaglandin f2 alpha
animal experiment
endocrine system
estrus
female genital system
in vitro study
nidation
rat
uterus contractility
Animals
Dinoprost
Dinoprostone
Embryo Implantation
Epoprostenol
Estrus
Female
Indomethacin
Myometrium
Pregnancy
Prostaglandins E
Prostaglandins F
Rats
Rats, Inbred Strains
Uterine Contraction
Uterus
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00316989_v13_n7_p679_Gimeno
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:The spontaneous isometric developed tension (IDT) and the frequency of contractions (FC) of the implantation or linea uteri (LU) and the non implantation or myometrial region (M) from uterine horns in different stages of the sex cycle were studied. The functional activity (FA= IDT × FC) of LU and M decreased with time comparably in proestrus and metestrus whereas during estrus the stability was significantly higher in the implantation region than in M. In uterine strips isolated from proestrus animals indomethacin (2; 5 or 10 μg/ml) did not change the functional activity neither of LU nor of M; on the contrary in metestrus, indomethacin diminished significantly the functional activity of both uterine regions. When the uterine strips (M and LU) were obtained from animals in estrus, only the implantation region was depressed by indomethacin at the 3 concentrations tested. The release of PGE and PGF-like material by incubated strips of M and LU obtained from estrus rats was also studied. The PGE-like material generated by the implantation zone was significantly higher than that released by non implantation region. Regarding PGF-like material, the spontaneous release was similar in M and LU. On the other hand PGI2-like material generated by LU and M was not significantly different. The probable implications of the differences found in these two regions of the estrus uterus are discussed. © 1981 The Italian Pharmacological Society.

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