Modafinil improves methamphetamine-induced object recognition deficits and restores prefrontal cortex ERK signaling in mice

Chronic use of methamphetamine (METH) leads to long-lasting cognitive dysfunction in humans and in animal models. Modafinil is a wake-promoting compound approved for the treatment of sleeping disorders. It is also prescribed off label to treat METH dependence. In the present study, we investigated w...

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Detalles Bibliográficos
Autores principales:	González, B., Raineri, M., Cadet, J.L., García-Rill, E., Urbano, F.J., Bisagno, V.
Formato:	JOUR
Materias:	ERK Methamphetamine Modafinil Novelty Prefrontal cortex methamphetamine mitogen activated protein kinase 1 mitogen activated protein kinase 3 modafinil benzhydryl derivative central stimulant agent mitogen activated protein kinase nootropic agent animal experiment animal model Article cognitive defect controlled study dose response enzyme phosphorylation exploratory behavior habituation hippocampus male medial prefrontal cortex memory disorder mouse nonhuman novel object recognition test nucleus accumbens palliative therapy prefrontal cortex signal transduction single drug dose visual memory animal C57BL mouse chemically induced drug effects Memory Disorders metabolism motor activity neuropsychological test pathophysiology phosphorylation physiology recognition vision withdrawal syndrome Animals Benzhydryl Compounds Central Nervous System Stimulants Dose-Response Relationship, Drug Exploratory Behavior Extracellular Signal-Regulated MAP Kinases Hippocampus Male MAP Kinase Signaling System Mice, Inbred C57BL Motor Activity Neuropsychological Tests Nootropic Agents Nucleus Accumbens Phosphorylation Prefrontal Cortex Recognition (Psychology) Substance Withdrawal Syndrome Visual Perception
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_00283908_v87_n_p188_Gonzalez
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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