The role of the D2 dopamine receptor (D2R) in A2A adenosine receptor (A2AR)-mediated behavioral and cellular responses as revealed by A2A and D2 receptor knockout mice

The A2AR is largely coexpressed with D2Rs and enkephalin mRNA in the striatum where it modulates dopaminergic activity. Activation of the A2AR antagonizes D2R-mediated behavioral and neurochemical effects in the basal ganglia through a mechanism that may involve direct A2AR-D2R interaction. However,...

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Detalles Bibliográficos
Autores principales:	Chen, J.-F., Moratalla, R., Impagnatiello, F., Grandy, D.K., Cuellar, B., Rubinstein, M., Beilstein, M.A., Hackett, E., Fink, J.S., Low, M.J., Ongini, E., Schwarzschild, M.A.
Formato:	JOUR
Materias:	8 (3 chlorostyryl)caffeine adenosine A2a receptor adenosine A2a receptor agonist adenosine A2a receptor antagonist adenosine receptor blocking agent amphetamine derivative caffeine dopamine 2 receptor dopamine 2 receptor blocking agent enkephalin haloperidol animal behavior animal experiment animal model article controlled study dopaminergic activity drug effect knockout mouse locomotion motor activity mouse nerve conduction neurotransmission nonhuman priority journal protein expression receptor down regulation Adenosine Amphetamines Animals Caffeine Catalepsy Corpus Striatum Dopamine Antagonists Enkephalins Gene Expression Haloperidol Mice Mice, Inbred C57BL Mice, Knockout Motor Activity Phenethylamines Receptor, Adenosine A2A Receptors, Dopamine D1 Receptors, Dopamine D2 Receptors, Purinergic P1 RNA, Messenger Animalia
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_00278424_v98_n4_p1970_Chen
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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