Reduced facilitation and vesicular uptake in crustacean and mammalian neuromuscular junction by T-588, a neuroprotective compound

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Bath application of compound T-588, a neuroprotective agent, reduced paired-pulse and repetitive-pulse facilitation at mammalian and crustacean neuromuscular junctions. In addition, it reduced voltage-gated sodium and potassium currents in a use-dependent fashion, but had only a small effect on the...

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Detalles Bibliográficos
Autores principales: Hirata, K., Nakagawa, M., Urbano, F.J., Rosato-Siri, M.D., Moreira, J.E., Uchitel, O.D., Sugimori, M., Llinás, R.
Formato: JOUR
Materias:
FM 1-43
Two-photon microscopy
Ultrastructure
Voltage clamp
1 (benzo[b]thien 5 yl) 2 (2 diethylaminoethoxy)ethanol
acetylcholine release
animal cell
article
calcium conductance
cell death
cell ultrastructure
drug effect
facilitation
mouse
nerve cell
neuromuscular synapse
neuroprotection
nonhuman
potassium current
priority journal
sodium current
synaptic transmission
Action Potentials
Animals
Astacoidea
Calcium
Diethylamines
Endocytosis
Glutamic Acid
Male
Mice
Neuromuscular Junction
Neuroprotective Agents
Potassium Channels
Sodium Channels
Synaptic Transmission
Synaptic Vesicles
Thiophenes
Animalia
Crustacea
Mammalia
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00278424_v96_n25_p14588_Hirata
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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