Local frustration around enzyme active sites

Conflicting biological goals often meet in the specification of protein sequences for structure and function. Overall, strong energetic conflicts are minimized in folded native states according to the principle of minimal frustration, so that a sequence can spontaneously fold, but local violations o...

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Detalles Bibliográficos
Autores principales: Freiberger, M.I., Brenda Guzovsky, A., Wolynes, P.G., Gonzalo Parra, R., Ferreiro, D.U.
Formato: JOUR
Materias:
Bioinformatics
Catalytic sites
Evolution
Local frustration
Protein enzymes
article
bioinformatics
catalysis
enzyme active site
enzyme activity
frustration
oligomerization
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00278424_v116_n10_p4037_Freiberger
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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