Islet 1 specifies the identity of hypothalamic melanocortin neurons and is critical for normal food intake and adiposity in adulthood

Food intake and body weight regulation depend on proper expression of the proopiomelanocortin gene (Pomc) in a group of neurons located in the mediobasal hypothalamus of all vertebrates. These neurons release POMC-encoded melanocortins, which are potent anorexigenic neuropeptides, and their absence...

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Detalles Bibliográficos
Autores principales: Nasif, S., De Souza, F.S.J., González, L.E., Yamashita, M., Orquera, D.P., Low, M.J., Rubinstein, M.
Formato: JOUR
Materias:
Hypothalamus
Isl1
Melanocortin
Obesity
Pomc
beta tubulin
beta tubulin iii
calbindin 1
caspase 3
corticotropin
LIM homeodomain protein
lim homeodomain transcription factor islet 1
melanocortin
monoclonal antibody
neurogenin 3
neuropeptide
nPE1 protein
nPE2 protein
proopiomelanocortin
protein
tamoxifen
transcription factor
transcription factor Mash1
unclassified drug
insulin gene enhancer binding protein Isl-1
protein binding
adult
adulthood
animal experiment
animal model
Article
binding affinity
binding site
body weight
brain region
cell differentiation
controlled study
DNA binding motif
embryo
embryo development
enhancer region
food intake
gene expression
gene mutation
human
hyperphagia
hypothalamus
immunocompetent cell
in vitro study
in vivo study
lifespan
mediobasal hypothalamus
nerve cell
nervous system development
nonhuman
obesity
ontogeny
pathophysiology
priority journal
reporter gene
satiety
transactivation
transgenic zebrafish
zebra fish
animal
cytology
eating
embryology
female
fluorescence microscopy
gene expression regulation
gene silencing
genetics
knockout mouse
male
metabolism
molecular genetics
nucleotide sequence
physiology
reverse transcription polymerase chain reaction
sequence homology
transgenic mouse
Danio rerio
Mus
Vertebrata
Adiposity
Animals
Base Sequence
Cell Differentiation
Eating
Female
Gene Expression Regulation, Developmental
Gene Knockdown Techniques
Hyperphagia
LIM-Homeodomain Proteins
Male
Mice, Knockout
Mice, Transgenic
Microscopy, Fluorescence
Molecular Sequence Data
Neurons
Pro-Opiomelanocortin
Protein Binding
Reverse Transcriptase Polymerase Chain Reaction
Sequence Homology, Nucleic Acid
Transcription Factors
Zebrafish
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00278424_v112_n15_pE1861_Nasif
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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