Involvement of bone morphogenetic protein 4 (BMP-4) in pituitary prolactinoma pathogenesis through a Smad/estrogen receptor crosstalk

Pituitary tumor development involves clonal expansion stimulated by hormones and growth factors/cytokines. Using mRNA differential display, we found that the bone morphogenetic protein (BMP inhibitor noggin is down-regulated in prolactinomas from dopamine D2-receptor-deficient mice. BMP-4 is overexp...

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Detalles Bibliográficos
Autores principales:	Páez-Pereda, M., Giacomini, D., Refojo, D., Nagashima, A.C., Hopfner, U., Grübler, Y., Chervin, A., Goldberg, V., Goya, R., Hentges, S.T., Low, M.J., Holsboer, F., Stalla, G.K., Arzt, E.
Formato:	JOUR
Materias:	Pituitary neoplasms Signal transduction bone morphogenetic protein 4 cytokine dopamine 2 receptor estradiol estrogen receptor fulvestrant growth factor hormone derivative messenger RNA noggin Smad protein Smad1 protein transforming growth factor beta unclassified drug animal cell animal experiment animal model article carcinogenicity cell proliferation controlled study down regulation female gene overexpression hypophysis adenoma hypophysis tumor mouse nonhuman nude mouse oncogene c myc pathogenesis priority journal prolactinoma protein protein interaction signal transduction tumor growth Western blotting Animals Blotting, Western Bone Morphogenetic Proteins Cell Division DNA-Binding Proteins Estrogens Female Gene Expression Profiling Heterozygote Humans Mice Mice, Nude Pituitary Neoplasms Plasmids Precipitin Tests Prolactinoma Proto-Oncogene Proteins c-myc Rats Rats, Sprague-Dawley Receptors, Dopamine D2 Receptors, Estrogen Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger Signal Transduction Smad4 Protein Time Factors Trans-Activators Transcription Factors Transfection Animalia Mus musculus
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_00278424_v100_n3_p1034_PaezPereda
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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