Histamine H2 receptor desensitization: Involvement of a select array of G protein-coupled receptor kinases

The histamine H2 receptor (H2r) belongs to the heptahelical receptor family; upon agonist binding, members of this family activate a G protein and the downstream effector adenylyl cyclase. Like other G protein-coupled receptors, exposure of H2r to agonists produces a desensitization of the response....

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Detalles Bibliográficos
Autores principales: Shayo, C., Fernandez, N., Legnazzi, B.L., Monczor, F., Mladovan, A., Baldi, A., Davio, C.
Formato: JOUR
Materias:
adenylate cyclase
amthamine
cyclic AMP
cyclic AMP dependent protein kinase
cyclic AMP dependent protein kinase inhibitor
G protein coupled receptor
G protein coupled receptor kinase
G protein coupled receptor kinase 2
G protein coupled receptor kinase 5
G protein coupled receptor kinase 6
histamine
histamine H2 receptor
protein GRK3
protein kinase C inhibitor
protein kinase inhibitor
unclassified drug
animal cell
article
controlled study
DNA transfection
enzyme active site
enzyme inhibition
enzyme kinetics
enzyme mechanism
enzyme regulation
enzyme specificity
histamine release
nonhuman
priority journal
protein phosphorylation
receptor binding
receptor down regulation
signal transduction
transcription termination
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_0026895X_v60_n5_p1049_Shayo
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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