Epigenetic modifications in the biology of nonalcoholic fatty liver disease: The role of DNA hydroxymethylation and TET proteins

The 5-Hydroxymethylcytosine (5-hmC) is an epigenetic modification whose role in the pathogenesis of metabolic-related complex diseases remains unexplored; 5-hmC appears to be prevalent in the mitochondrial genome. The Ten-Eleven-Translocation (TET) family of proteins is responsible for catalyzing th...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Pirola, C.J., Scian, R., Gianotti, T.F., Dopazo, H., Rohr, C., Martino, J.S., Castaño, G.O., Sookoian, S.
Formato:	JOUR
Materias:	5 hydroxymethylcytosine cytokeratin 18 messenger RNA mitochondrial DNA peptides and proteins peroxisome proliferator activated receptor gamma coactivator 1alpha ten eleven translocation 1 protein ten eleven translocation 2 protein ten eleven translocation 3 protein unclassified drug 5-hydroxymethylcytosine cytosine DNA binding protein heat shock protein oncoprotein PPARGC1A protein, human TET1 protein, human transcription factor abdominal obesity adult apoptosis Article controlled study disease severity DNA methylation DNA modification epigenetics female gene dosage gene locus genetic susceptibility genetic variability histopathology human human tissue hypertension hypertriglyceridemia immunohistochemistry insulin resistance liver biopsy liver fibrosis liver histology liver mitochondrion major clinical study male middle aged mitochondrial genome next generation sequencing non insulin dependent diabetes mellitus nonalcoholic fatty liver observational study priority journal protein expression protein methylation single nucleotide polymorphism steatosis analogs and derivatives genetic epigenesis genetic predisposition genetics liver metabolism Non-alcoholic Fatty Liver Disease organelle biogenesis pathology Adult Cytosine DNA Methylation DNA-Binding Proteins Epigenesis, Genetic Female Genetic Predisposition to Disease Heat-Shock Proteins Humans Liver Male Middle Aged Mitochondria, Liver Organelle Biogenesis Proto-Oncogene Proteins Transcription Factors
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_00257974_v94_n36_p_Pirola
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

Ejemplares similares

Epigenetic modifications in the biology of nonalcoholic fatty liver disease: The role of DNA hydroxymethylation and TET proteins
Publicado: (2015)

Mitochondrial genome architecture in non-alcoholic fatty liver disease
Publicado: (2016)

Mitochondrial genome architecture in non-alcoholic fatty liver disease
por: Sookoian, S., et al.

Protein malnutrition during fetal programming induces fatty liver in adult male offspring rats
Publicado: (2017)

Protein malnutrition during fetal programming induces fatty liver in adult male offspring rats
por: Campisano, S.E., et al.

Expression Pattern of Fatty Acid Binding Proteins in Celiac Disease Enteropathy
por: Bottasso Arias, Natalia María, et al.
Publicado: (2015)

Atypical epigenetic mark in an atypical location: Cytosine methylation at asymmetric (CNN) sites within the body of a non-repetitive tomato gene
por: Gonzalez, Rodrigo Matias, et al.
Publicado: (2011)

Atypical epigenetic mark in an atypical location: Cytosine methylation at asymmetric (CNN) sites within the body of a non-repetitive tomato gene
por: González, R.M., et al.
Publicado: (2011)

Atypical epigenetic mark in an atypical location: Cytosine methylation at asymmetric (CNN) sites within the body of a non-repetitive tomato gene
por: González, R.M., et al.

Atypical epigenetic mark in an atypical location: Cytosine methylation at asymmetric (CNN) sites within the body of a non-repetitive tomato gene
por: González, R.M., et al.
Publicado: (2011)

CTCF: From insulators to alternative splicing regulation
por: Kornblihtt, Alberto Rodolfo
Publicado: (2012)

CTCF: From insulators to alternative splicing regulation
por: Kornblihtt, A.R.

The arabidopsis DNA polymerase δ has a role in the deposition of transcriptionally active epigenetic marks, development and flowering
por: Iglesias, Francisco Manuel, et al.
Publicado: (2015)

The arabidopsis DNA polymerase δ has a role in the deposition of transcriptionally active epigenetic marks, development and flowering
por: Iglesias, F.M., et al.

Alternation between dietary protein depletion and normal feeding cause liver damage in mouse
por: Caballero, Veronica Jorgelina, et al.
Publicado: (2010)

Interaction of the -170 cyclic AMP response element with the adjacent CCAAT box in the human fibronectin gene promoter
Publicado: (1992)

Interaction of the -170 cyclic AMP response element with the adjacent CCAAT box in the human fibronectin gene promoter
por: Muro, A.F., et al.

Liver diseases biochemical mechanisms and new therapeutic insights.
Publicado: (2006)

Fatty liver disease, a silent killer of human beings /
por: Saha, Ashis Kumar
Publicado: (2020)

Conjugated linoleic acid and fatty acid binding protein as antioxidants
por: Piergiacomi, Viviana Angélica, et al.
Publicado: (2006)

Dynamic coregulatory complex containing BRCA1, E2F1 and CtIP controls ATM transcription
por: Moiola, Cristian Pablo, et al.
Publicado: (2012)

Dynamic coregulatory complex containing BRCA1, E2F1 and CtIP controls ATM transcription
por: Moiola, C., et al.

Alternation between dietary protein depletion and normal feeding cause liver damage in mouse
Publicado: (2011)

Alternation between dietary protein depletion and normal feeding cause liver damage in mouse
por: Caballero, V.J., et al.

Gene expression regulation by heat-shock proteins: the cardinal roles of HSF1 and Hsp90
Publicado: (2018)

Gene expression regulation by heat-shock proteins: the cardinal roles of HSF1 and Hsp90
por: Mazaira, G.I., et al.

Delta-aminolevulinic acid cytotoxic effects on human hepatocarcinoma cell lines.
por: De Siervi, Adriana, et al.
Publicado: (2002)

Delta-aminolevulinic acid cytotoxic effects on human hepatocarcinoma cell lines.
por: De Siervi, A., et al.

Retroviral-like features in the monomer of the major satellite DNA from the south american rodents of the genus ctenomys
por: Rossi, Maria Susana, et al.
Publicado: (1993)

Retroviral-like features in the monomer of the major satellite DNA from the south american rodents of the genus ctenomys
por: Rossi, M.S., et al.

Liver
Publicado: (1981)

Liver international official journal of the International Association for the Study of the Liver.
Publicado: (2003)

Chromatin, DNA structure and alternative splicing
por: Giono, Luciana Eugenia, et al.
Publicado: (2015)

Chromatin, DNA structure and alternative splicing
por: Nieto Moreno, N., et al.

Th17 involvement in nonalcoholic fatty liver disease progression to non-alcoholic steatohepatitis
por: Chackelevicius, Carla Melisa, et al.
Publicado: (2016)

Effect of in vivo administered hexachlorobenzene on epidermal growth factor receptor levels, protein tyrosine kinase activity, and phosphotyrosine content in rat liver
por: Randi, Andrea Silvana, et al.
Publicado: (2003)

Effect of in vivo administered hexachlorobenzene on epidermal growth factor receptor levels, protein tyrosine kinase activity, and phosphotyrosine content in rat liver
por: Randi, A.S., et al.

Suppression of homologous and homeologous recombination by the bacterial MutS2 protein
por: Ielpi, Luis, et al.
Publicado: (2005)

Suppression of homologous and homeologous recombination by the bacterial MutS2 protein
por: Pinto, A.V., et al.
Publicado: (2005)

Suppression of homologous and homeologous recombination by the bacterial MutS2 protein
por: Pinto, A.V., et al.