Chagasic IgG modifies the activity of sarcolemmal ATPases through a β adrenergic mechanism

The effect of anti β adrenoceptor IgG from chagasic sera upon Ca2+-ATPase and Na++K+-ATPase of myocardial membrane was studied. Chagasic IgG stimulated Ca2+-ATPase and inhibited Na++K+-ATPase activities. Both enzymatic effects of the IgG could be prevented after β adrenoceptor blockade or after the...

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Detalles Bibliográficos
Autores principales: Pascual, J., Borda, E., Sterin-Borda, L.
Formato: JOUR
Materias:
adenosine triphosphatase (calcium magnesium)
adenosine triphosphatase (calcium)
adenosine triphosphatase (potassium sodium)
Adrenergic beta Agonists
beta adrenergic receptor
beta adrenergic receptor stimulating agent
Ca(2+) Mg(2+) ATPase
Ca(2+) Transporting ATPase
immunoglobulin G
isoprenaline
Na(+) K(+) Exchanging ATPase
propranolol
adult
animal
article
Chagas disease
enzymology
erythrocyte
guinea pig
human
immunology
male
metabolism
physiology
sarcolemma
turkey (bird)
Adrenergic beta-Agonists
Adult
Animal
Ca(2+) Mg(2+)-ATPase
Ca(2+)-Transporting ATPase
Chagas Disease
Erythrocytes
Guinea Pigs
Human
Immunoglobulin G
Isoproterenol
Male
Na(+)-K(+)-Exchanging ATPase
Propranolol
Receptors, Adrenergic, beta
Sarcolemma
Support, Non-U.S. Gov't
Turkeys
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00243205_v40_n4_p313_Pascual
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:The effect of anti β adrenoceptor IgG from chagasic sera upon Ca2+-ATPase and Na++K+-ATPase of myocardial membrane was studied. Chagasic IgG stimulated Ca2+-ATPase and inhibited Na++K+-ATPase activities. Both enzymatic effects of the IgG could be prevented after β adrenoceptor blockade or after the absorption of chagasic IgG with turkey red blood cells. Isoproterenol acted similarly. These results provide information concerning to the biochemical mechanism, by which an antibody, known to activate adenylate cyclase system coupled to cardiac β adrenoceptor, produces stimulation of myocardial contractility. © 1987.

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