Mitochondrial genome architecture in non-alcoholic fatty liver disease

Non-alcoholic fatty liver disease (NAFLD) is associated with mitochondrial dysfunction, a decreased liver mitochondrial DNA (mtDNA) content, and impaired energy metabolism. To understand the clinical implications of mtDNA diversity in the biology of NAFLD, we applied deep-coverage whole sequencing o...

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Detalles Bibliográficos
Autores principales: Sookoian, S., Flichman, D., Scian, R., Rohr, C., Dopazo, H., Gianotti, T.F., Martino, J.S., Castaño, G.O., Pirola, C.J.
Formato: JOUR
Materias:
fatty liver
gene expression
liver fibrosis
mitochondrial dysfunction
mitochondrial genome
NASH
non-alcoholic fatty liver disease
cytochrome c oxidase
DNA directed DNA polymerase gamma
glutamine
histidine
mitochondrial DNA
reduced nicotinamide adenine dinucleotide dehydrogenase
transfer RNA
adult
Article
body mass
clinical article
comparative study
controlled study
disease severity
DNA content
electron microscopy
female
follow up
gene frequency
gene locus
gene sequence
genetic variability
heteroplasmy
histopathology
human
human tissue
immunoreactivity
liver biopsy
male
middle aged
missense mutation
mitochondrial DNA replication
mutation rate
nonalcoholic fatty liver
oxidative phosphorylation
phenotype
point mutation
POLG gene
POLG2 gene
priority journal
protein expression
replication study
sequence analysis
single nucleotide polymorphism
case control study
genetic polymorphism
genetic predisposition
genetics
germline mutation
haplotype
liver cirrhosis
liver mitochondrion
mutation
severity of illness index
Adult
Case-Control Studies
DNA, Mitochondrial
Female
Genetic Predisposition to Disease
Genome, Mitochondrial
Germ-Line Mutation
Haplotypes
Humans
Liver Cirrhosis
Male
Middle Aged
Mitochondria, Liver
Mutation
Mutation, Missense
Non-alcoholic Fatty Liver Disease
Oxidative Phosphorylation
Polymorphism, Genetic
Severity of Illness Index
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00223417_v240_n4_p437_Sookoian
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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