Kinetic recognition of the retinoblastoma tumor suppressor by a specific protein target

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The retinoblastoma tumor suppressor (Rb) plays a key role in cell cycle control and is linked to various types of human cancer. Rb binds to the LxCxE motif, present in a number of cellular and viral proteins such as AdE1A, SV40 large T-antigen and human papillomavirus (HPV) E7, all instrumental in r...

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Detalles Bibliográficos
Autores principales: Chemes, L.B., Sánchez, I.E., De Prat-Gay, G.
Formato: JOUR
Materias:
intrinsically disordered proteins
LxCxE motif
phosphorylation
retinoblastoma protein
viral oncoprotein
protein E7
retinoblastoma binding protein
virus protein
article
cancer inhibition
cell cycle regulation
gene expression
Human papillomavirus type 16
molecular recognition
priority journal
protein conformation
protein domain
protein motif
protein protein interaction
protein targeting
Simian virus 40
tumor suppressor gene
Amino Acid Sequence
Kinetics
Models, Molecular
Molecular Sequence Data
Papillomavirus E7 Proteins
Protein Binding
Retinoblastoma Protein
Sequence Homology, Amino Acid
Thermodynamics
Human papillomavirus
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00222836_v412_n2_p267_Chemes
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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