Folding kinetics of the cooperatively folded subdomain of the IκBα ankyrin repeat domain

The ankyrin repeat (AR) domain of IκBα consists of a cooperative folding unit of roughly four ARs (AR1-AR4) and of two weakly folded repeats (AR5 and AR6). The kinetic folding mechanism of the cooperative subdomain, IκBα 67-206, was analyzed using rapid mixing techniques. Despite its apparent archit...

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Detalles Bibliográficos
Autores principales: Devries, I., Ferreiro, D.U., Sánchez, I.E., Komives, E.A.
Formato: JOUR
Materias:
α value; folding landscapeNFκB
protein folding
repeat protein
ankyrin
ankyrin 1
ankyrin 2
ankyrin 3
ankyrin 4
ankyrin 5
ankyrin 6
I kappa B alpha
mutant protein
unclassified drug
article
gene deletion
gene mutation
human
kinetics
priority journal
protein analysis
protein stability
temperature
Amino Acid Sequence
Ankyrin Repeat
Ankyrins
Consensus Sequence
Humans
I-kappa B Proteins
Kinetics
Models, Molecular
Molecular Sequence Data
Mutation
Protein Folding
Sequence Homology, Amino Acid
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00222836_v408_n1_p163_Devries
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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