Acyclic analogues of deoxyadenosine 3',5'-bisphosphates as P2Y 1 receptor antagonists

P2Y 1 receptors are activated by ADP and occur on endothelial cells, smooth muscle, epithelial cells, lungs, pancreas, platelets, and in the central nervous system. With the aid of molecular modeling, we have designed nucleotide analogues that act as selective antagonists at this subtype. The presen...

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Detalles Bibliográficos
Autores principales: Kim, Y.-C., Gallo-Rodriguez, C., Jang, S.-Y., Nandanan, E., Adams, M., Harden, T.K., Boyer, J.L., Jacobson, K.A.
Formato: JOUR
Materias:
2 [2 (2 chloro 6 methylaminopurin 9 yl)ethyl]propane 1,3 bisoxy(diammoniumphosphate)
2 [2 (6 methylaminopurin 9 yl)ethyl]propane 1,3 bisoxy(diammoniumphosphate)
deoxyadenosine derivative
ethylene derivative
ganciclovir
phospholipase C
purine P2Y receptor
purinergic receptor blocking agent
receptor subtype
unclassified drug
animal cell
article
cis isomer
controlled study
drug potency
drug receptor binding
drug structure
drug synthesis
enzyme activation
nonhuman
reaction analysis
receptor blocking
structure activity relation
trans isomer
Adenine
Deoxyadenosines
Diphosphonates
Erythrocytes
Inositol Phosphates
Phosphoric Acid Esters
Receptors, Purinergic P2
Structure-Activity Relationship
Turkey
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00222623_v43_n4_p746_Kim
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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