Programmed death (PD)-1:PD-ligand 1/PD-ligand 2 pathway inhibits T cell effector functions during human tuberculosis

Protective immunity against Mycobacterium tuberculosis requires the generation of cell-mediated immunity. We investigated the expression and role of programmed death 1 (PD-1) and its ligands, molecules known to modulate T cell activation, in the regulation of IFN-γ production and lytic degranulation...

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Autores principales:	Jurado, J.O., Alvarez, I.B., Pasquinelli, V., Martínez, G.J., Quiroga, M.F., Abbate, E., Musella, R.M., Chuluyan, H.E., García, V.E.
Formato:	JOUR
Materias:	gamma interferon inhibitor protein ligand pd 1 ligand pd 2 ligand programmed death 1 protein receptor protein unclassified drug antigen apoptosis regulatory protein CD150 antigen CD274 protein, human cell surface receptor leukocyte antigen PDCD1 protein, human PDCD1LG2 protein, human signal peptide article CD3+ T lymphocyte CD8+ T lymphocyte cellular immunity cytokine production degranulation human priority journal protein expression protein function signal transduction T lymphocyte activation tuberculosis biosynthesis cell culture immunology lymphocyte activation metabolism Mycobacterium tuberculosis protein binding T lymphocyte Antigens Antigens, CD Apoptosis Regulatory Proteins Cells, Cultured Humans Intercellular Signaling Peptides and Proteins Interferon Type II Lymphocyte Activation Protein Binding Receptors, Cell Surface Signal Transduction T-Lymphocytes Tuberculosis
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_00221767_v181_n1_p116_Jurado
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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