Strong cytosine-guanosine-independent immunostimulation in humans and other primates by synthetic oligodeoxynucleotides with PyNTTTTGT motifs

Synthetic oligodeoxynucleotides (ODNs) containing cytosine-guanosine (CpG) motifs stimulate B and plasmacytoid dendritic cells of the vertebrate immune system. We found that in primates strong stimulation of these cells could also be achieved using certain non-CpG ODNs. The immunostimulatory motif i...

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Detalles Bibliográficos
Autores principales:	Elias, F., Flo, J., Lopez, R.A., Zorzopulos, J., Montaner, A., Rodriguez, J.M.
Formato:	JOUR
Materias:	adenosine bacterial DNA cytosine guanosine nuclease oligonucleotide phosphorothioic acid thymidine animal cell article B lymphocyte cell damage cell stimulation controlled study dendritic cell human human cell immune system immunostimulation nonhuman nucleotide sequence primate priority journal protein motif vertebrate
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_00221767_v171_n7_p3697_Elias
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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