Interferon-γ inhibits cellular proliferation and ACTH production in corticotroph tumor cells through a novel janus kinases-signal transducer and activator of transcription 1/nuclear factor-kappa B inhibitory signaling pathway

Interferon-γ (IFNG) is a cytokine that exerts potent antiproliferative and tumoricidal effects in a variety of cancers. Moreover, IFNG modulates normal pituitary hormone secretion, and was shown to inhibit the expression of the ACTH precursor POMC in murine ACTH-secreting AtT-20 tumor cells. We have...

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Detalles Bibliográficos
Autores principales: Labeur, M., Refojo, D., Wölfel, B., Stalla, J., Vargas, V., Theodoropoulou, M., Buchfelder, M., Paez-Pereda, M., Arzt, E., Stalla, G.K.
Formato: JOUR
Materias:
corticotropin
gamma interferon
gamma interferon receptor
gamma interferon receptor 1
gamma interferon receptor 2
immunoglobulin enhancer binding protein
Janus kinase
proopiomelanocortin
STAT1 protein
unclassified drug
ACTH secreting adenoma
animal cell
article
cell proliferation
controlled study
corticotropin release
Cushing disease
gene expression regulation
gene repression
hormone synthesis
human
human cell
human tissue
hypophysis cell
mouse
nonhuman
priority journal
promoter region
regulatory mechanism
signal transduction
transcription regulation
Adrenocorticotropic Hormone
Animals
Blotting, Western
Cell Proliferation
Humans
Interferon-gamma
Janus Kinases
Mice
NF-kappa B
Pituitary Neoplasms
Pro-Opiomelanocortin
Reverse Transcriptase Polymerase Chain Reaction
Signal Transduction
STAT1 Transcription Factor
Transcription, Genetic
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00220795_v199_n2_p177_Labeur
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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