Fast axonal transport of the proteasome complex depends on membrane interaction and molecular motor function

Protein degradation by the ubiquitin-proteasome system in neurons depends on the correct delivery of the proteasome complex. In neurodegenerative diseases, aggregation and accumulation of proteins in axons link transport defects with degradation impairments; however, the transport properties of prot...

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Detalles Bibliográficos
Autores principales: Otero, M.G., Alloatti, M., Cromberg, L.E., Almenar-Queralt, A., Encalada, S.E., Devoto, V.M.P., Bruno, L., Goldstein, L.S.B., Falzone, T.L.
Formato: JOUR
Materias:
Axonal transport
Kinesin-1
Membrane interaction
Molecular motors
Proteasome
Vesicles
molecular motor
proteasome
ubiquitin
animal tissue
article
axoneme
clearance
controlled study
degenerative disease
diffusion
Golgi complex
in vivo study
intracellular membrane
lysosome
mitochondrion
molecular interaction
motor unit
mouse
nerve fiber transport
nonhuman
priority journal
protein degradation
synapse vesicle
viscoelasticity
animal
C57BL mouse
cell culture
cytology
hippocampus
metabolism
nerve fiber
physiology
sciatic nerve
synaptosome
transport at the cellular level
Animals
Axonal Transport
Axons
Biological Transport
Cells, Cultured
Hippocampus
Intracellular Membranes
Mice
Mice, Inbred C57BL
Proteasome Endopeptidase Complex
Sciatic Nerve
Synaptic Vesicles
Synaptosomes
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00219533_v127_n7_p1537_Otero
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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