Hyperactivation of the human plasma membrane Ca2+ pump PMCA h4xb by mutation of Glu99 to Lys

The transport of calcium to the extracellular space carried out by plasma membrane Ca2+ pumps (PMCAs) is essential for maintaining low Ca 2+ concentrations in the cytosol of eukaryotic cells. The activity of PMC Asis controlled by autoinhibition. Autoinhibition is relieved by the binding of Ca2+-cal...

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Detalles Bibliográficos
Autores principales: Mazzitelli, L.R., Adamo, H.P.
Formato: JOUR
Materias:
Calmodulin
Cell membranes
Molecules
Pumps
Autoinhibitory domain
C-terminal segments
Eukaryotic cells
Extracellular space
Intramolecular interactions
Maximal velocity
Negatively charged
Transmembrane helices
Calcium
adenosine triphosphatase (calcium)
calcium
calmodulin
glutamic acid
green fluorescent protein
h4xb plasma membrane calcium pump
lysine
unclassified drug
amino acid substitution
article
controlled study
cytosol
enzyme activity
enzyme conformation
mutation
priority journal
ATPases
Calcium ATPase
Calcium Transport
Enzymes
Transporters
Catalysis
Cell Membrane
Cytosol
Gene Deletion
Glutamine
Green Fluorescent Proteins
Humans
Lysine
Mutation
Plasma Membrane Calcium-Transporting ATPases
Protein Binding
Protein Isoforms
Protein Structure, Tertiary
Saccharomyces cerevisiae
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00219258_v289_n15_p10761_Mazzitelli
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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