Multidrug resistance protein 4 (MRP4/ABCC4) regulates cAMP cellular levels and controls human leukemia cell proliferation and differentiation

Increased intracellular cAMP concentration plays a well established role in leukemic cell maturation. We previously reported that U937 cells stimulated by H2 receptor agonists, despite a robust increase in cAMP, fail to mature because of rapid H2 receptor desensitization and phosphodiesterase (PDE)...

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Detalles Bibliográficos
Autores principales: Copsel, S., Garcia, C., Diez, F., Vermeulem, M., Baldi, A., Bianciotti, L.G., Russel, F.G.M., Shayo, C., Davio, C.
Formato: JOUR
Materias:
Acute myeloid leukemia
Cellular levels
Human leukemia cells
Intracellular cAMP
Leukemic cells
Multidrug resistance
PDE4 inhibitor
Phosphodiesterases
Probenecid
U937 cell
Cell culture
Cell proliferation
Diseases
Extrusion
Fetal monitoring
adenosine triphosphate
amthamine
cyclic AMP
multidrug resistance protein
multidrug resistance protein 4
phosphodiesterase IV inhibitor
probenecid
short hairpin RNA
acute granulocytic leukemia
article
cell cycle arrest
cell differentiation
cell maturation
cell proliferation
cell strain HL 60
cell strain U937
controlled study
human
human cell
leukemia cell
leukemia cell line
priority journal
protein transport
Cell Differentiation
Cell Division
Cyclic AMP
Drug Design
HL-60 Cells
Humans
Leukemia, Myeloid, Acute
Multidrug Resistance-Associated Proteins
Phosphodiesterase 4 Inhibitors
RNA, Small Interfering
Rolipram
Signal Transduction
Thiazoles
U937 Cells
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00219258_v286_n9_p6979_Copsel
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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