The catalytic domain of insulin-degrading enzyme forms a denaturant-resistant complex with amyloid β peptide: Implications for Alzheimer disease pathogenesis

Insulin-degrading enzyme (IDE) is central to the turnover of insulin and degrades amyloid β (Aβ) in the mammalian brain. Biochemical and genetic data support the notion that IDE may play a role in late onset Alzheimer disease (AD), and recent studies suggest an association between AD and diabetes me...

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Autores principales:	Llovera, R.E., De Tullio, M., Alonso, L.G., Leissring, M.A., Kaufman, S.B., Roher, A.E., Gay, G.D.P., Morelli, L., Castaño, E.M.
Formato:	JOUR
Materias:	Amines Binding energy Binding sites Colloids Diffusers (optical) Enzymes Flow interactions Forming Gelation Glycoproteins High performance liquid chromatography Hormones Insulin Mammals Mass spectrometry A stables After treatments Alzheimer diseases Catalytic domains Catalytic sites Complex formations Cortical tissues Degrading enzymes Diabetes Mellitus Genetic datums Limited proteolyses Mammalian brains Molar excesses Partial denaturations Rat brains Soluble fractions Substrate bindings Terminal fragments Integrodifferential equations amyloid beta protein dodecyl sulfate sodium insulinase recombinant enzyme Alzheimer disease amino terminal sequence article binding site complex formation controlled study enzyme active site enzyme denaturation human human tissue nonhuman pathogenesis priority journal protein conformation protein degradation protein domain protein folding protein protein interaction rat animal biological model brain chemistry enzyme specificity kinetics mass spectrometry metabolism pathology protein binding radiation scattering Mammalia Rattus Alzheimer Disease Amyloid beta-Protein Animals Binding Sites Brain Catalytic Domain Humans Insulysin Kinetics Mass Spectrometry Models, Biological Protein Binding Rats Scattering, Radiation Substrate Specificity
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_00219258_v283_n25_p17039_Llovera
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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