The Gα12/13 family of heterotrimeric G proteins and the small GTPase RhoA link the Kaposi sarcoma-associated herpes virus G protein-coupled receptor to heme oxygenase-1 expression and tumorigenesis

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Heme oxygenase-1 (HO-1), an inducible enzyme that metabolizes the heme group, is highly expressed in human Kaposi sarcoma lesions. Its expression is up-regulated by the G protein-coupled receptor from the Kaposi sarcoma-associated herpes virus (vGPCR). Although recent evidence shows that HO-1 contri...

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Detalles Bibliográficos
Autores principales: Martín, M.J., Tanos, T., García, A.B., Martin, D., Gutkind, J.S., Coso, O.A., Marinissen, M.J.
Formato: JOUR
Materias:
Kaposi sarcoma lesions
Oncogenic activity
Tumor growth
Tumorigenesis
Cells
Enzyme activity
Gene expression
RNA
Tumors
Proteins
G protein coupled receptor
guanine nucleotide binding protein
guanine nucleotide binding protein alpha12
guanine nucleotide binding protein alpha13
guanosine triphosphatase
heme oxygenase 1
heme oxygenase inhibitor
heterotrimeric guanine nucleotide binding protein
protoporphyrin
RhoA guanine nucleotide binding protein
short hairpin RNA
unclassified drug
vasculotropin A
chemokine receptor
G protein coupled receptor, Human herpesvirus 8
G protein-coupled receptor, Human herpesvirus 8
guanine nucleotide binding protein alpha subunit
photosensitizing agent
RHOA protein, human
VEGFA protein, human
allograft
animal cell
animal experiment
animal model
article
carcinogenesis
cell proliferation
cell strain 3T3
cell survival
controlled study
enzyme activity
human
human cell
Human herpesvirus 8
Kaposi sarcoma
mouse
nonhuman
nude mouse
priority journal
protein expression
protein function
tumor growth
animal
drug antagonism
drug effect
drug screening
gene expression regulation
genetics
metabolism
promoter region
secretion
virus cell transformation
Herpesviridae
Murinae
Mus
Mus musculus
Animals
Cell Transformation, Viral
Gene Expression Regulation, Neoplastic
GTP-Binding Protein alpha Subunits, Gq-G11
Heme Oxygenase-1
Herpesvirus 8, Human
Humans
Mice
Mice, Nude
NIH 3T3 Cells
Photosensitizing Agents
Promoter Regions (Genetics)
Protoporphyrins
Receptors, Chemokine
rhoA GTP-Binding Protein
Vascular Endothelial Growth Factor A
Xenograft Model Antitumor Assays
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00219258_v282_n47_p34510_Martin
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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