Trypanosoma cruzi arginine kinase characterization and cloning. A novel energetic pathway in protozoan parasites

This work contains the first description of a guanidino kinase in a flagellar unicellular parasite. The enzyme phosphorylates L-arginine and was characterized in preparations from Trypanosoma cruzi, the ethiological agent of Chagas' disease. The activity requires ATP and a divalent cation. Unde...

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Detalles Bibliográficos
Autores principales: Pereira, C.A., Alonso, G.D., Paveto, M.C., Iribarren, A., Cabanas, M.L., Torres, H.N., Flawiá, M.M.
Formato: JOUR
Materias:
adenosine triphosphate
arginine
arginine kinase
canavanine
divalent cation
guanidine derivative
histidine
messenger RNA
phosphotransferase
amino acid sequence
article
Chagas disease
drug targeting
energy transfer
enzyme activity
enzyme analysis
enzyme inhibition
molecular cloning
molecular weight
nonhuman
nucleotide sequence
open reading frame
priority journal
protozoon
Trypanosoma cruzi
Amino Acid Sequence
Amino Acids
Animals
Arginine Kinase
Base Sequence
Cations, Divalent
Chromatography, Affinity
Chromosome Mapping
Cloning, Molecular
Genomic Library
Humans
Kinetics
Molecular Sequence Data
Phylogeny
Recombinant Proteins
Sequence Alignment
Sequence Homology, Amino Acid
Arthropoda
Mammalia
Protozoa
Trypanosoma
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00219258_v275_n2_p1495_Pereira
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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