Inhibition of aldosterone production in rat adrenal mitochondria by 18-ethynyl-11-deoxycorticosterone: A simple model for kinetic interpretation of mechanism-based inhibitors

A simple mathematical model for studying mechanism-based inhibitors (MBIs) is presented. The mathematical equations are deduced for an experimental protocol consisting of a first incubation of the enzyme in the presence of MBI followed by a washing protocol to eliminate free MBI. Finally enzyme acti...

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Detalles Bibliográficos
Autores principales:	Matkovic, L., Gomez-Sanchez, C.E., Cozza, E.N.
Formato:	JOUR
Materias:	18-ethynyl-11-deoxycorticosterone Adrenal gland Aldosterone Mechanism-based inhibitors Suicide inhibitors 18 ethynyl 11 deoxycorticosterone aldosterone deoxycorticosterone suicide substrate unclassified drug adrenal gland animal cell animal tissue article controlled study enzyme activity enzyme mechanism enzyme substrate mathematical model mitochondrion nonhuman rat Animalia
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_0021924X_v129_n3_p383_Matkovic
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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