Association of thoracic aorta calcium and non cardiac vascular events in cardiac disease-free individuals

Objective: Thoracic aorta calcium (TAC) is measurable on the same computed tomography (CT) scan as coronary artery calcium (CAC) but has still unclear clinical value. We assessed TAC and CAC relations with non-cardiac vascular events history in a cohort of subjects at risk for cardiovascular disease...

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Detalles Bibliográficos
Autores principales: Craiem, D., Chironi, D.G., Casciaro, M.E., Sirieix, M.-E., Mousseaux, E., Simon, A.
Formato: JOUR
Materias:
Cardiovascular risk
Cerebrovascular disease
Coronary artery calcium
Peripheral vascular disease
Vascular calcification
calcium
thoracic aorta calcium
unclassified drug
adult
Agatston score
aorta arch
Article
calcification
cardiovascular risk
computer assisted tomography
coronary risk
female
heart disease
human
major clinical study
male
multidetector computed tomography
priority journal
retrospective study
risk
Aortic Diseases
Argentina
calcinosis
clinical trial
complication
coronary angiography
coronary artery disease
diagnostic imaging
follow up
France
incidence
metabolism
middle aged
multicenter study
risk assessment
thoracic aorta
Aorta, Thoracic
Calcinosis
Calcium
Coronary Angiography
Coronary Artery Disease
Female
Follow-Up Studies
Humans
Incidence
Male
Middle Aged
Multidetector Computed Tomography
Retrospective Studies
Risk Assessment
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00219150_v245_n_p22_Craiem
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:Objective: Thoracic aorta calcium (TAC) is measurable on the same computed tomography (CT) scan as coronary artery calcium (CAC) but has still unclear clinical value. We assessed TAC and CAC relations with non-cardiac vascular events history in a cohort of subjects at risk for cardiovascular disease. Methods: We analyzed retrospectively 1000 consecutive subjects having undergone CAC detection by non-contrast multi-slice CT with measurement field longer than usual in order to measure total TAC including aortic arch calcium. We also determined partial TAC restricted to ascending and descending thoracic aorta sites by removing arch calcium from total TAC. Calcium deposits were measured with a custom made software using Agatston score. Results: Compared with the rest of the cohort, the 30 subjects with non-cardiac vascular event history had higher median values [95% CI] of total TAC (282 [28-1809] vs 39 [0-333], p < 0.01) and partial TAC (4 [0-284] vs 0 [0-5], p < 0.01) but no different value of CAC (73 [0-284] vs 16 [0-148]). Odds ratio [95% CI] of having non-cardiac vascular event per 1-SD increase in log-transformed calcium value was significant for total TAC but not for CAC, if total TAC and CAC were entered separately (1.56 [1.12-2.24], p < 0.01 and 1.13 [0.86-1.50], respectively) or together (1.57 [1.10-2.32], p < 0.01 and 0.98 [0.73-1.32], respectively) in the logistic adjusted model. Conclusion: TAC assessment simultaneous with CAC detection provides complementary information on the extra coronary component of cardiovascular risk beyond CAC's coronary risk prediction. Further studies are required to prospectively confirm this result. © 2015.

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