Poly(ADP-ribose) polymerase plays a differential role in DNA damage-response and cell death pathways in Trypanosoma cruzi

Poly(ADP-ribosyl)ation is a post-translational modification of proteins. Poly(ADP-ribose) polymerase (PARP) and poly(ADP-ribose) glycohydrolase (PARG) are the enzymes responsible for poly(ADP-ribose) (PAR) polymer metabolism and are present in most higher eukaryotes. The best understood role of PARP...

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Detalles Bibliográficos
Autores principales: Vilchez Larrea, S.C., Alonso, G.D., Schlesinger, M., Torres, H.N., Flawiá, M.M., Fernández Villamil, S.H.
Formato: JOUR
Materias:
Cell death
DNA repair
PARG
PARP
Trypanosoma cruzi
hydrogen peroxide
nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase
DNA
eukaryote
genotoxicity
inhibitor
metabolism
parasite
polymerase chain reaction
protein
apoptosis
article
cell growth
cell nucleus
controlled study
cytosol
DNA damage
enzyme activation
enzyme activity
gene translocation
nonhuman
nuclear localization signal
nucleotide sequence
protein expression
ultraviolet radiation
Animals
Cell Death
Cell Nucleus
DNA Damage
DNA Repair
Glycoside Hydrolases
Poly(ADP-ribose) Polymerases
Protozoan Proteins
Eukaryota
Protista
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00207519_v41_n3_p405_VilchezLarrea
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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