Neuroprotective action of synthetic steroids with oxygen bridge. Activity on GABAA receptor

Allopregnanolone (A) and pregnanolone (P) are able to modify neural activities acting through the GABAA receptor complex. This capacity makes them useful as anticonvulsant, anxiolytic, or anti-stress compounds. In this study, the performance of seven synthetic steroids (SS) analogous of A or P conta...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Rey, M., Kruse, M.S., Alvarez, L.D., Ghini, A.A., Veleiro, A.S., Burton, G., Coirini, H.
Formato: JOUR
Materias:
3β-HSD
Cerebellum
Hippocampus
Hypothalamus
Hypoxia
Neurosteroids
3alpha hydroxy 11alpha,19 epoxypregn 4 ene 20 one
3alpha hydroxy 1alpha,11alpha epoxy 5alpha pregnan 20 one
3alpha hydroxy 1alpha,11alpha epoxypregn 4 ene 20 one
3alpha hydroxy 1beta,11alpha epoxy 5alpha pregnan 20 one
3alpha hydroxy 2alpha,19 epoxy 5alpha pregnan 20 one
3alpha hydroxy 4alpha,19 epoxy 5alpha pregnan 20 one
3alpha hydroxy 5alpha pregnan 20 one
3alpha hydroxy 6,19 epoxypregn 4 ene 20 one
4 aminobutyric acid A receptor
eltanolone
flunitrazepam
glial fibrillary acidic protein
muscimol
steroid
unclassified drug
animal experiment
animal tissue
article
astrocytosis
binding affinity
binding site
brain cortex
brain hypoxia
brain region
cerebellum
controlled study
drug efficacy
drug mechanism
drug receptor binding
drug response
drug structure
enzyme activity
hippocampus
hypoxia
ligand binding
male
mouse
neurofilament
neuroprotection
nonhuman
priority journal
rat
Animals
Dose-Response Relationship, Drug
Male
Neuroprotective Agents
Organ Culture Techniques
Oxygen
Protein Binding
Rats
Rats, Sprague-Dawley
Receptors, GABA-A
Steroids
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00144886_v249_n_p49_Rey
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

Ejemplares similares

Ejemplares similares