Bromocriptine and sulpiride competitively inhibit estrogen binding to its receptor in the adrenal gland
Bromocriptine and sulpiride incubated simultaneously with [3H]-estradiol in the cytosol from adrenal glands of adult male rats, yielded curves typical of competitive inhibition as analyzed by Lineweaver-Burk plots. The inhibition constant for both drugs was approximately 108 M-1, only 10 times lower...
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| Formato: | JOUR |
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_00144754_v42_n2_p136_Luthy |
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todo:paper_00144754_v42_n2_p136_Luthy2023-10-03T14:12:32Z Bromocriptine and sulpiride competitively inhibit estrogen binding to its receptor in the adrenal gland Lüthy, I.A. Calandra, R.S. adrenal bromocriptine Estrogen receptors sulpiride bromocriptine corticotropin estradiol radioisotope sulpiride adrenal gland animal cell drug administration drug efficacy drug interaction drug receptor binding endocrine system estradiol h 3 estrogen binding etiology methodology nonhuman pharmacokinetics priority journal rat Adrenal Glands Animal Binding, Competitive Bromocriptine Cytosol Estradiol Male Rats Rats, Inbred Strains Receptors, Estradiol Receptors, Estrogen Sulpiride Bromocriptine and sulpiride incubated simultaneously with [3H]-estradiol in the cytosol from adrenal glands of adult male rats, yielded curves typical of competitive inhibition as analyzed by Lineweaver-Burk plots. The inhibition constant for both drugs was approximately 108 M-1, only 10 times lower than the association constant for estradiol. © 1986 Birkhäuser Verlag Basel. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00144754_v42_n2_p136_Luthy |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
adrenal bromocriptine Estrogen receptors sulpiride bromocriptine corticotropin estradiol radioisotope sulpiride adrenal gland animal cell drug administration drug efficacy drug interaction drug receptor binding endocrine system estradiol h 3 estrogen binding etiology methodology nonhuman pharmacokinetics priority journal rat Adrenal Glands Animal Binding, Competitive Bromocriptine Cytosol Estradiol Male Rats Rats, Inbred Strains Receptors, Estradiol Receptors, Estrogen Sulpiride |
| spellingShingle |
adrenal bromocriptine Estrogen receptors sulpiride bromocriptine corticotropin estradiol radioisotope sulpiride adrenal gland animal cell drug administration drug efficacy drug interaction drug receptor binding endocrine system estradiol h 3 estrogen binding etiology methodology nonhuman pharmacokinetics priority journal rat Adrenal Glands Animal Binding, Competitive Bromocriptine Cytosol Estradiol Male Rats Rats, Inbred Strains Receptors, Estradiol Receptors, Estrogen Sulpiride Lüthy, I.A. Calandra, R.S. Bromocriptine and sulpiride competitively inhibit estrogen binding to its receptor in the adrenal gland |
| topic_facet |
adrenal bromocriptine Estrogen receptors sulpiride bromocriptine corticotropin estradiol radioisotope sulpiride adrenal gland animal cell drug administration drug efficacy drug interaction drug receptor binding endocrine system estradiol h 3 estrogen binding etiology methodology nonhuman pharmacokinetics priority journal rat Adrenal Glands Animal Binding, Competitive Bromocriptine Cytosol Estradiol Male Rats Rats, Inbred Strains Receptors, Estradiol Receptors, Estrogen Sulpiride |
| description |
Bromocriptine and sulpiride incubated simultaneously with [3H]-estradiol in the cytosol from adrenal glands of adult male rats, yielded curves typical of competitive inhibition as analyzed by Lineweaver-Burk plots. The inhibition constant for both drugs was approximately 108 M-1, only 10 times lower than the association constant for estradiol. © 1986 Birkhäuser Verlag Basel. |
| format |
JOUR |
| author |
Lüthy, I.A. Calandra, R.S. |
| author_facet |
Lüthy, I.A. Calandra, R.S. |
| author_sort |
Lüthy, I.A. |
| title |
Bromocriptine and sulpiride competitively inhibit estrogen binding to its receptor in the adrenal gland |
| title_short |
Bromocriptine and sulpiride competitively inhibit estrogen binding to its receptor in the adrenal gland |
| title_full |
Bromocriptine and sulpiride competitively inhibit estrogen binding to its receptor in the adrenal gland |
| title_fullStr |
Bromocriptine and sulpiride competitively inhibit estrogen binding to its receptor in the adrenal gland |
| title_full_unstemmed |
Bromocriptine and sulpiride competitively inhibit estrogen binding to its receptor in the adrenal gland |
| title_sort |
bromocriptine and sulpiride competitively inhibit estrogen binding to its receptor in the adrenal gland |
| url |
http://hdl.handle.net/20.500.12110/paper_00144754_v42_n2_p136_Luthy |
| work_keys_str_mv |
AT luthyia bromocriptineandsulpiridecompetitivelyinhibitestrogenbindingtoitsreceptorintheadrenalgland AT calandrars bromocriptineandsulpiridecompetitivelyinhibitestrogenbindingtoitsreceptorintheadrenalgland |
| _version_ |
1807314461743120384 |