Bromocriptine and sulpiride competitively inhibit estrogen binding to its receptor in the adrenal gland

Bromocriptine and sulpiride incubated simultaneously with [3H]-estradiol in the cytosol from adrenal glands of adult male rats, yielded curves typical of competitive inhibition as analyzed by Lineweaver-Burk plots. The inhibition constant for both drugs was approximately 108 M-1, only 10 times lower...

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Detalles Bibliográficos
Autores principales: Lüthy, I.A., Calandra, R.S.
Formato: JOUR
Materias:
adrenal
bromocriptine
Estrogen receptors
sulpiride
corticotropin
estradiol
radioisotope
adrenal gland
animal cell
drug administration
drug efficacy
drug interaction
drug receptor binding
endocrine system
estradiol h 3
estrogen binding
etiology
methodology
nonhuman
pharmacokinetics
priority journal
rat
Adrenal Glands
Animal
Binding, Competitive
Bromocriptine
Cytosol
Estradiol
Male
Rats
Rats, Inbred Strains
Receptors, Estradiol
Receptors, Estrogen
Sulpiride
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00144754_v42_n2_p136_Luthy
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:Bromocriptine and sulpiride incubated simultaneously with [3H]-estradiol in the cytosol from adrenal glands of adult male rats, yielded curves typical of competitive inhibition as analyzed by Lineweaver-Burk plots. The inhibition constant for both drugs was approximately 108 M-1, only 10 times lower than the association constant for estradiol. © 1986 Birkhäuser Verlag Basel.

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