Is prostacyclin subserving a vasodilator effect of methoxamine involving alpha adrenoreceptors?

The influence of methoxamine on the contractile tension of isolated rat abdominal aorta, and on its capacity to produce a platelet antiaggregating substance, were explored. Methoxamine stimulated platelet antiaggregation and diminished arterial tone. The last action was blocked by phentolamine as we...

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Detalles Bibliográficos
Autores principales: Borda, E., Sterin-Borda, L., Gimeno, M.F., Lazzari, M., Gimeno, A.L.
Formato: JOUR
Materias:
4 aminophenol
acetylsalicylic acid
alpha adrenergic receptor
indometacin
methoxamine
phentolamine
propranolol
prostacyclin
prostacyclin synthase
tranylcypromine
animal cell
ant
aorta
drug efficacy
great blood vessel
nonhuman
rat
Animals
Aorta, Abdominal
Epoprostenol
Indomethacin
Male
Methoxamine
Muscle Contraction
Platelet Aggregation
Prostaglandins
Rats
Rats, Inbred Strains
Receptors, Adrenergic
Receptors, Adrenergic, alpha
Vasodilator Agents
Animalia
Formicidae
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00144754_v39_n8_p894_Borda
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:The influence of methoxamine on the contractile tension of isolated rat abdominal aorta, and on its capacity to produce a platelet antiaggregating substance, were explored. Methoxamine stimulated platelet antiaggregation and diminished arterial tone. The last action was blocked by phentolamine as well as by inhibitiors of cyclo-oxygenase and prostacyclinsynthetase. © 1983 Birkhäuser Verlag.

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