An adrenergic participation subserving a positive inotropism and chronotropism of prostacyclin on isolated rat atria

The effects of prostacyclin (PGI2) on the contractile frequency and on the isometric developed tension of spontaneously beating or paced isolated rat atria were explored. PGI2 enhanced frequency and contractile tension, both effects being blocked by the presence of propranolol, or following a pretre...

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Detalles Bibliográficos
Autores principales: Borda, L.S., Cangas, L., Gimeno, M.F., Gimeno, A.L.
Formato: JOUR
Materias:
oxidopamine
propranolol
prostacyclin
prostaglandin
animal experiment
central nervous system
heart
heart atrium
heart contraction
heart muscle contractility
heart rate
in vitro study
inotropism
isolated heart
rat
Animal
Epoprostenol
Heart Rate
Hydroxydopamines
In Vitro
Male
Myocardial Contraction
Propranolol
Prostaglandins
Rats
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00144754_v35_n4_p529_Borda
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:The effects of prostacyclin (PGI2) on the contractile frequency and on the isometric developed tension of spontaneously beating or paced isolated rat atria were explored. PGI2 enhanced frequency and contractile tension, both effects being blocked by the presence of propranolol, or following a pretreatment with 6-OHDopamine. © 1979 Birkhäuser Verlag.

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