Inhibitory effect of quercetin on matrix metalloproteinase 9 activity Molecular mechanism and structure-activity relationship of the flavonoid-enzyme interaction

Epidemiological studies have demonstrated an inverse association between the consumption of flavonoid-rich diets and the risk of atherosclerosis. In addition, an increased activity of the matrix metalloproteinase 9 (MMP-9) has been implicated in the development and progression of atherosclerotic les...

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Detalles Bibliográficos
Autores principales: Saragusti, A.C., Ortega, M.G., Cabrera, J.L., Estrin, D.A., Marti, M.A., Chiabrando, G.A.
Formato: JOUR
Materias:
Diet polyphenol
Docking
Flavonoid
Molecular dynamics
Zymography
chrysin
fisetin
galangin
gelatinase B
kaempferol
luteolin
morin
quercetin
article
binding site
controlled study
drug mechanism
drug protein binding
drug structure
enzyme active site
enzyme inhibition
enzyme kinetics
human
human cell
IC 50
molecular docking
molecular dynamics
priority journal
structure activity relation
structure analysis
zymography
Antioxidants
Binding Sites
Cell Line, Tumor
Enzyme Inhibitors
Flavonoids
Humans
Inhibitory Concentration 50
Matrix Metalloproteinase 9
Models, Molecular
Protein Binding
Quercetin
Structure-Activity Relationship
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00142999_v644_n1-3_p138_Saragusti
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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