Inhibition of the α9α10 nicotinic cholinergic receptor by neramexane, an open channel blocker of N-methyl-d-aspartate receptors

In this study we report the effects of neramexane, a novel amino-alkyl-cyclohexane derivative that is a non-competitive N-methyl-d-aspartate (NMDA) receptor antagonist, on recombinant rat α9α10 nicotinic acetylcholine receptors expressed in Xenopus laevis oocytes. We compared its effects with those...

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Detalles Bibliográficos
Autores principales: Plazas, P.V., Savino, J., Kracun, S., Gomez-Casati, M.E., Katz, E., Parsons, C.G., Millar, N.S., Elgoyhen, A.B.
Formato: JOUR
Materias:
Acetylcholine
Hair cells
N-methyl-d-aspartate receptor antagonist
Neramexane
Nicotinic acetylcholine receptors
cyclohexane derivative
memantine
n methyl dextro aspartic acid receptor blocking agent
neramexane
nicotinic receptor
radioligand
acetylcholine
cyclopentane derivative
n methyl dextro aspartic acid receptor
nicotinic receptor blocking agent
protein subunit
recombinant protein
Alzheimer disease
article
cell membrane potential
controlled study
desensitization
drug binding
drug inhibition
drug potency
drug protein binding
embryo
genetic transfection
hair cell
human
human cell
in vivo study
kinetics
nonhuman
oocyte
priority journal
protein expression
rat
Xenopus laevis
animal
cell line
drug antagonism
drug effect
genetics
metabolism
physiology
Sprague Dawley rat
Animals
Cell Line
Cyclopentanes
Hair Cells, Inner
Humans
Memantine
Nicotinic Antagonists
Oocytes
Protein Subunits
Rats
Rats, Sprague-Dawley
Receptors, N-Methyl-D-Aspartate
Receptors, Nicotinic
Recombinant Proteins
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00142999_v566_n1-3_p11_Plazas
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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