Functional activation by central monoamines of human dopamine D4 receptor polymorphic variants coupled to GIRK channels in Xenopus oocytes

We studied the functional activation of different polymorphic variants of the human dopamine D4 receptors by the three major central monoamines, dopamine, noradrenaline and serotonin. Dopamine D4 receptors carrying two (D4.2), four (D4.4) or seven (D4.7) repeats within the third intracellular domain...

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Detalles Bibliográficos
Autores principales: Wedemeyer, C., Goutman, J.D., Avale, M.E., Franchini, L.F., Rubinstein, M., Calvo, D.J.
Formato: JOUR
Materias:
Dopamine D4 receptor
GIRK channels
Noradrenaline
Polymorphic variants
Serotonin
dopamine
dopamine 4 receptor
dopamine receptor blocking agent
G protein coupled inwardly rectifying potassium channel
monoamine
noradrenalin
serotonin
sonepiprazole
allele
animal cell
article
controlled study
frog
gene expression
genetic polymorphism
genetic variability
ion current
nonhuman
oocyte
priority journal
protein domain
protein expression
receptor upregulation
sequence analysis
voltage clamp
Xenopus laevis
Alleles
Amino Acid Sequence
Animals
Dopamine
Dose-Response Relationship, Drug
Drug Delivery Systems
Drug Design
Electrophysiology
Female
G Protein-Coupled Inwardly-Rectifying Potassium Channels
GTP-Binding Protein alpha Subunits, Gi-Go
Humans
Norepinephrine
Oocytes
Polymorphism, Genetic
Receptors, Dopamine D4
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00142999_v562_n3_p165_Wedemeyer
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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