Selective disruption of dopamine D2 receptors in pituitary lactotropes increases body weight and adiposity in female mice

Prolactin, a pleiotropic hormone secreted by lactotropes, has reproductive and metabolic functions. Chronically elevated prolactin levels increase food intake, but in some hyperprolactinemic states such as in the global dopamine D2 receptor (D2R) knockout mouse, food intake is not increased. Here, w...

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Detalles Bibliográficos
Autores principales: Millan, M.I.P., Luque, G.M., Ramirez, M.C., Noain, D., Ornstein, A.M., Rubinstein, M., Becu-Villalobos, D.
Formato: JOUR
Materias:
dopamine 2 receptor
fatty acid
insulin
prolactin
adipocyte
adipose tissue
animal experiment
animal model
article
body weight
cell disruption
controlled study
fatty acid blood level
female
food intake
gene disruption
gene expression
glucose intolerance
hyperplasia
hyperprolactinemia
hypothalamus
lipid storage
male
mouse
nonhuman
null allele
obesity
pathophysiology
priority journal
prolactin blood level
prolactin secreting cell
triacylglycerol blood level
weight gain
Adipose Tissue
Adiposity
Animals
Body Weight
Eating
Estrous Cycle
Female
Genotype
Glucose Intolerance
Glucose Tolerance Test
Insulin
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Pituitary Gland
Prolactin
Receptors, Dopamine D2
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00137227_v155_n3_p829_Millan
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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