Thrombospondin-1 (TSP-1) analogs ABT-510 and ABT-898 inhibit prolactinoma growth and recover active pituitary transforming growth factor-β1 (TGF-β1)

Prolactinomas are the most prevalent type of secreting pituitary tumors in humans and generally respond well to a medical therapy with dopamine agonists. However, for patients exhibiting resistance to dopaminergic drugs, alternative treatments are desired. Antiangiogenic strategies might represent a...

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Detalles Bibliográficos
Autores principales:	Recouvreux, M.V., Camilletti, M.A., Rifkin, D.B., Becu-Villalobos, D., Díaz-Torga, G.
Formato:	JOUR
Materias:	abt 898 angiogenesis inhibitor n acetylsarcosylglycylvalyl dextro alloisoleucylthreonylnorvalylisoleucylarginylproline ethylamide prolactin thrombospondin 1 transforming growth factor beta1 unclassified drug animal experiment animal model antiangiogenic activity article cell proliferation controlled study drug effect female hypophysis nonhuman priority journal prolactin blood level prolactinoma rat treatment duration tumor growth Animals Diethylstilbestrol Female Oligopeptides Prolactinoma Rats Rats, Sprague-Dawley Thrombospondin 1 Transforming Growth Factor beta1
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_00137227_v153_n8_p3861_Recouvreux
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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