Disruption of the dopamine D2 receptor impairs insulin secretion and causes glucose intolerance

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The relationship between antidopaminergic drugs and glucose has not been extensively studied, even though chronic neuroleptic treatment causes hyperinsulinemia in normal subjects or is associated with diabetes in psychiatric patients. We sought to evaluate dopamine D2 receptor (D2R) participation in...

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Detalles Bibliográficos
Autores principales: García-Tornadú, I., Ornstein, A.M., Chamson-Reig, A., Wheeler, M.B., Hill, D.J., Arany, E., Rubinstein, M., Becu-Villalobos, D.
Formato: JOUR
Materias:
cabergoline
dopamine 2 receptor
haloperidol
animal cell
animal experiment
animal model
animal tissue
article
cell division
cell isolation
drug mechanism
glucose homeostasis
glucose intolerance
immunohistochemistry
in vitro study
in vivo study
insulin release
insulin tolerance test
male
mouse
nonhuman
pancreas function
pancreas islet beta cell
pancreas islet cell
priority journal
Analysis of Variance
Animals
Blood Glucose
Cell Proliferation
Dopamine Agonists
Dopamine Antagonists
Ergolines
Female
Glucose
Glucose Intolerance
Haloperidol
Immunohistochemistry
Insulin
Insulin-Like Growth Factor I
Male
Mice
Mice, Knockout
Pancreas
Prolactin
Radioimmunoassay
Receptors, Dopamine D2
Time Factors
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00137227_v151_n4_p1441_GarciaTornadu
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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