Glucocorticoid-induced impairment of mammary gland involution is associated with STAT5 and STAT3 signaling modulation

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The mammary epithelium undergoes cyclical periods of cellular proliferation, differentiation, and regression. During lactation, the signal transducer and activator of transcription factor (STAT)-5A and the glucocorticoid receptor (GR) synergize to induce milk protein expression and also act as survi...

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Detalles Bibliográficos
Autores principales: Bertucci, P.Y., Quaglino, A., Pozzi, A.G., Kordon, E.C., Pecci, A.
Formato: JOUR
Materias:
beta casein
dexamethasone
glucocorticoid
prolactin
STAT3 protein
STAT5 protein
animal experiment
animal tissue
apoptosis
article
down regulation
epithelium cell
extracellular matrix
gene expression
mammary gland
mouse
nonhuman
priority journal
protein degradation
signal transduction
weaning
Animals
Cytokine Receptor gp130
Dexamethasone
DNA Fragmentation
Female
Gene Expression Regulation
Glucocorticoids
Lactation
Leukemia Inhibitory Factor
Mammary Glands, Animal
Mice
Mice, Inbred BALB C
Signal Transduction
STAT3 Transcription Factor
STAT5 Transcription Factor
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00137227_v151_n12_p5730_Bertucci
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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