Retinoic acid as a novel medical therapy for Cushing's disease in dogs

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Cushing's disease is almost always caused by an ACTH-secreting pituitary tumor, but effective medical therapy is currently limited. Because retinoic acid has been shown to be potentially useful in decreasing corticotroph secretion and proliferation in rodent models, we have studied its action i...

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Detalles Bibliográficos
Autores principales: Castillo, V., Giacomini, D., Páez-Pereda, M., Stalla, J., Labeur, M., Theodoropoulou, M., Holsboer, F., Grossman, A.B., Stalla, G.K., Arzt, E.
Formato: JOUR
Materias:
alpha intermedin
corticotropin
creatinine
hydrocortisone
ketoconazole
retinoic acid
animal experiment
animal model
article
controlled study
corticotropin blood level
creatinine urine level
Cushing disease
dog
drug efficacy
drug safety
female
hormone blood level
hydrocortisone urine level
hypophysis
hypophysis adenoma
male
nonhuman
nuclear magnetic resonance imaging
priority journal
survival
tumor volume
Adenoma
Adrenocorticotropic Hormone
alpha-MSH
Animals
Body Weight
Creatinine
Dog Diseases
Dogs
Female
Hydrocortisone
Ketoconazole
Magnetic Resonance Imaging
Male
Pituitary ACTH Hypersecretion
Pituitary Gland
Pituitary Neoplasms
Survival Rate
Tretinoin
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00137227_v147_n9_p4438_Castillo
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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