Disruption of the D2 dopamine receptor alters GH and IGF-I secretion and causes dwarfism in male mice

We determined the consequences of the loss of D2 receptors (D2R) on the GH-IGF-I axis using mice deficient in functional dopamine D2 receptors by targeted mutagenesis (D2R-/-). Body weights were similar at birth, but somatic growth was less in male D2R-/- mice from 1-8 months of age and in D2R-/- fe...

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Detalles Bibliográficos
Autores principales:	Díaz-Torga, G., Feierstein, C., Libertun, C., Gelman, D., Kelly, M.A., Low, M.J., Rubinstein, M., Becú-Villalobos, D.
Formato:	JOUR
Materias:	8 chloro 2,3,4,5 tetrahydro 3 methyl 5 phenyl 1h 3 benzazepin 7 ol hydrogen maleate DNA dopamine 1 receptor blocking agent dopamine 2 receptor dopamine 2 receptor blocking agent growth hormone growth hormone releasing factor prolactin somatomedin B somatomedin binding protein 3 somatomedin C sulpiride adolescent animal cell animal experiment animal model animal tissue article body growth body weight bone maturation controlled study dwarfism female femur food intake growth hormone blood level growth hormone release in vitro study knockout mouse liver weight male mouse newborn nonhuman priority journal radioimmunoassay white adipose tissue
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_00137227_v143_n4_p1270_DiazTorga
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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