Defective signalling in salivary glands precedes the autoimmune response in the non-obese diabetic mouse model of sialadenitis

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The spontaneous non-obese diabetic (NOD) mouse model of Sjögren's syndrome provides a valuable tool to study the onset and progression of both the autoimmune response and secretory dysfunction. Our purpose was to analyse the temporal decline of salivary secretion in NOD mice in relation to the...

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Detalles Bibliográficos
Autores principales: Rosignoli, F., Roca, V., Meiss, R., Leceta, J., Gomariz, R.P., Leirós, C.P.
Formato: JOUR
Materias:
Autoimmune response
Nitric oxide signalling
NOD mice
Sialadenitis
Sjögren's syndrome
cyclic AMP
cyclic GMP
neurotransmitter
nitric oxide
nitric oxide synthase
vasoactive intestinal polypeptide
animal experiment
animal model
animal tissue
article
autoimmunity
cell infiltration
cytokine production
enzyme activity
female
immune response
mononuclear cell
mouse
mouse strain
nonhuman
parotid gland
priority journal
salivary gland
salivation
sialoadenitis
signal transduction
Sjoegren syndrome
submandibular gland
Animals
Autoantibodies
Autoimmunity
Cyclic GMP
Cytokines
Diabetes Mellitus, Type 1
Disease Models, Animal
Female
Mice
Mice, Inbred BALB C
Mice, Inbred NOD
Nitric Oxide Synthase
Parotid Gland
Salivary Glands
Signal Transduction
Submandibular Gland
Vasoactive Intestinal Peptide
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00099104_v142_n3_p411_Rosignoli
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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