Synthesis of β-galactosylamides as ligands of the peanut lectin. Insights into the recognition process

The synthesis of mono and divalent β-galactosylamides linked to a hydroxylated chain having a C2 symmetry axis derived from L-tartaric anhydride is reported. Reference compounds devoid of hydroxyl groups in the linker were also prepared from β-galactosylamine and succinic anhydride. After functional...

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Detalles Bibliográficos
Autores principales: Cano, M.E., Varela, O., García-Moreno, M.I., García Fernández, J.M., Kovensky, J., Uhrig, M.L.
Formato: JOUR
Materias:
Divalent ligands
ELLA assay
Molecular dynamics
Peanut agglutinin
β-galactosylamides
Binding energy
Chains
Chelation
Ligands
Oilseeds
Proteins
Scaffolds
Azide-alkyne cycloaddition
Binding affinities
Functionalizations
Lectin recognition
Recognition process
Reference compounds
Succinic anhydride
Copper compounds
aglycone
alkyne
amide
azide
beta galactosylamide
copper
hydroxyl group
lectin
ligand
succinic anhydride
unclassified drug
galactose
peanut agglutinin
protein binding
Article
catalysis
controlled study
cycloaddition
enzymatic assay
hydroxylation
IC50
molecular docking
molecular dynamics
molecular recognition
peanut
priority journal
synthesis
chemistry
metabolism
molecular model
protein conformation
Galactose
Models, Molecular
Peanut Agglutinin
Protein Binding
Protein Conformation
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00086215_v443-444_n_p58_Cano
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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