Diabetes alters the reactivity of myocardium to a thromboxane analogue

Atrial contractile response to U-46619 was studied in auricles from normal and acutely diabetic rats. U-46619 induced an increment of dF/dt in diabetic atria, whereas nondiabetic auricles elicited a negative contractile effect. Blockers of arachidonic acid metabolism via cyclooxygenase inhibited the...

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Detalles Bibliográficos
Autores principales:	Canga, L., Gorelik, G., Sterin-Borda, L.
Formato:	JOUR
Materias:	1 acetyl 2 (8 chloro 10,11 dihydrodibenz[b,f][1,4]oxazepine 10 carbonyl)hydrazine 15 hydroxy 11alpha,9alpha epoxymethanoprosta 5,13 dienoic acid acetylsalicylic acid dithizone imidazole indometacin lipoxygenase nictindole nordihydroguaiaretic acid prostaglandin synthase thromboxane derivative tranylcypromine animal animal cell diabetes mellitus dose response drug administration drug antagonism drug efficacy drug interaction drug mechanism endocrine system etiology heart heart muscle heart muscle contractility in vitro study pharmacokinetics priority journal rat
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_00084212_v65_n4_p499_Canga
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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