Interaction of cimetidine with P450 in a mouse model of hepatocarcinogenesis initiation

Many drugs and xenobiotics are lipophilic and they should be transformed into more polar water soluble compounds to be excreted. Cimetidine inhibits cytochrome P450. The aim of this study was to investigate the preventive and/or reversal action of cimetidine on cytochrome P450 induction and other me...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Caballero, F., Gerez, E., Batlle, A., Vazquez, E.
Formato:	JOUR
Materias:	Cimetidine Cytochrome P450 Haem metabolism Hepatocarcinogenesis Oxidative stress P-dimethylaminoazobenzene 4 dimethylaminoazobenzene 5 aminolevulinate synthase catalase cimetidine cytochrome P450 glutathione transferase heme heme oxygenase malonaldehyde thiobarbituric acid reactive substance xenobiotic agent animal experiment animal model animal tissue article controlled study enzyme induction enzyme inhibition lipid peroxidation liver cancer liver carcinogenesis liver injury male mouse nonhuman oxidative stress priority journal 5-Aminolevulinate Synthetase Animals Body Weight Carcinogens Catalase Cytochrome P-450 Enzyme System Enzyme Inhibitors Glutathione Transferase Heme Liver Neoplasms, Experimental Male Mice p-Dimethylaminoazobenzene Thiobarbituric Acid Reactive Substances
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_00070920_v86_n4_p630_Caballero
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

Ejemplares similares

Interaction of cimetidine with P450 in a mouse model of hepatocarcinogenesis initiation
por: Gerez, Esther Noemí, et al.
Publicado: (2002)

On the promoting action of tamoxifen in a model of hepatocarcinogenesis induced by p-dimethylaminoazobenzene in CF1 mice
por: Gerez, Esther Noemí, et al.
Publicado: (2001)

On the promoting action of tamoxifen in a model of hepatocarcinogenesis induced by p-dimethylaminoazobenzene in CF1 mice
por: Caballero, F., et al.

Hepatic enzymatic metabolism alterations and oxidative stress during the onset of carcinogenesis: Protective role of α-tocopherol
por: Gerez, Esther Noemí, et al.
Publicado: (1998)

Hepatic enzymatic metabolism alterations and oxidative stress during the onset of carcinogenesis: Protective role of α-tocopherol
por: Gerez, E., et al.

Drug metabolizing enzyme system and heme pathway in hepatocarcinogenesis
por: Vázquez, Elba Susana, et al.
Publicado: (1999)

Drug metabolizing enzyme system and heme pathway in hepatocarcinogenesis
por: Vazquez, E., et al.

Paraquat-generated oxidative stress in rat liver induces heme oxygenase-1 and aminolevulinic acid synthase
por: Noriega, Guillermo Osvaldo, et al.
Publicado: (2002)

Paraquat-generated oxidative stress in rat liver induces heme oxygenase-1 and aminolevulinic acid synthase
por: Noriega, G.O., et al.

Altered heme pathway regulation and drug metabolizing enzyme system in a mouse model of hepatocarcinogenesis: Effect of veronal
por: Gerez, Esther Noemí, et al.
Publicado: (1997)

Altered heme pathway regulation and drug metabolizing enzyme system in a mouse model of hepatocarcinogenesis: Effect of veronal
por: Gerez, E., et al.

Relevance of cytochrome P450 levels in the actions of enflurane and isoflurane in mice: Studies on the haem pathway
por: Buzaleh, Ana María, et al.
Publicado: (2000)

Relevance of cytochrome P450 levels in the actions of enflurane and isoflurane in mice: Studies on the haem pathway
por: Buzaleh, A.M., et al.

Heme biosynthesis pathway regulation in a model of hepatocarcinogenesis pre-initiation
por: Vázquez, Elba Susana, et al.
Publicado: (1992)

Heme biosynthesis pathway regulation in a model of hepatocarcinogenesis pre-initiation
por: Polo, C.F., et al.

Sevoflurane: Its action on heme metabolism and phase I drug metabolizing system
por: Lavandera, Jimena Verónica, et al.
Publicado: (2009)

Sevoflurane: Its action on heme metabolism and phase I drug metabolizing system
por: Sampayo, R., et al.

Hepatic damage and oxidative stress induced by griseofulvin in mice
por: Martínez, María del Carmen, et al.
Publicado: (2009)

Hepatic damage and oxidative stress induced by griseofulvin in mice
por: Martinez, M.D.C., et al.

Induction of hepatic aminolevulinate acid synthetase activity by isoflurane in a genetic model for erythropoietic protoporphyria
por: Buzaleh, Ana María, et al.
Publicado: (2009)

Induction of hepatic aminolevulinate acid synthetase activity by isoflurane in a genetic model for erythropoietic protoporphyria
por: Buzaleh, A.M., et al.
Publicado: (2009)

Induction of hepatic aminolevulinate acid synthetase activity by isoflurane in a genetic model for erythropoietic protoporphyria
por: Buzaleh, A.M., et al.

Induction of hepatic aminolevulinate acid synthetase activity by isoflurane in a genetic model for erythropoietic protoporphyria
por: Buzaleh, A.M., et al.
Publicado: (2009)

Heme regulation in mouse mammary carcinoma and liver of tumor bearing mice-I. Effect of allyl-isopropylacetamide and veronal on δ -aminolevulinate synthetase, cytochrome P-450 and cytochrome oxidase
por: Batlle, Alcira María del Carmen
Publicado: (1990)

Heme regulation in mouse mammary carcinoma and liver of tumor bearing mice-I. Effect of allyl-isopropylacetamide and veronal on δ -aminolevulinate synthetase, cytochrome P-450 and cytochrome oxidase
por: Navone, N.M., et al.
Publicado: (1990)

Heme regulation in mouse mammary carcinoma and liver of tumor bearing mice-I. Effect of allyl-isopropylacetamide and veronal on δ -aminolevulinate synthetase, cytochrome P-450 and cytochrome oxidase
por: Navone, N.M., et al.

Heme regulation in mouse mammary carcinoma and liver of tumor bearing mice-I. Effect of allyl-isopropylacetamide and veronal on δ -aminolevulinate synthetase, cytochrome P-450 and cytochrome oxidase
por: Navone, N.M., et al.
Publicado: (1990)

Effect of chronic anesthesia on the drug-metabolizing enzyme system and heme pathway regulation
por: Buzaleh, Ana María, et al.
Publicado: (1997)

Effect of chronic anesthesia on the drug-metabolizing enzyme system and heme pathway regulation
por: Buzaleh, A.M., et al.

Studies on the decrease of liver cytochrome P-450 content by triiodothyronine
por: Kleiman de Pisarev, Diana L., et al.
Publicado: (1991)

Studies on the decrease of liver cytochrome P-450 content by triiodothyronine
por: Kleiman de Pisarev, D.L., et al.

Regulation of heme pathway in regenerating mouse liver
por: Vázquez, Elba Susana
Publicado: (1992)

Regulation of heme pathway in regenerating mouse liver
por: Polo, C.F., et al.

Studies on regulatory mechanisms of heme biosynthesis in hepatocytes from experimental-diabetic rats
por: Cánepa, Eduardo Tomás, et al.
Publicado: (1985)

Studies on regulatory mechanisms of heme biosynthesis in hepatocytes from experimental-diabetic rats
por: Cánepa, E.T., et al.

Beta-carotene partially prevents the damage induced by 1,4- dimethylaminoazobenzene in mice
por: Gerez, Esther Noemí, et al.
Publicado: (1998)

Beta-carotene partially prevents the damage induced by 1,4- dimethylaminoazobenzene in mice
por: Gerez, E., et al.

Cyclophosphamide and its metabolite acrolein. Some studies on their porphyrinogenic action in 17 day old chick embryo.
por: Cochón, Adriana Cristina, et al.
Publicado: (1992)

Cyclophosphamide and its metabolite acrolein. Some studies on their porphyrinogenic action in 17 day old chick embryo.
por: Cochón, A.C., et al.

Immunohistochemical analysis of heme oxygenase-1 in preneoplastic and neoplastic lesions during chemical hepatocarcinogenesis
Publicado: (2004)