Changes in growth hormone and prolactin release after superior cervical ganglionectomy of rats

Superior cervical ganglionectomy (SCG×) decreased significantly serum growth hormone (GH) levels in rats 14-96 h after surgery, during and immediately after anterograde degeneration of regional sympathetic terminals. At later times (up to 28 days after SCG×) an increase in serum GH was observed. SCG...

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Detalles Bibliográficos
Autores principales: Cardinali, D.P., Boado, R.J., Vacas, M.I., Deza, S.
Formato: JOUR
Materias:
degeneration activity
growth hormone
noradrenaline
prolactin
superior cervical ganglion
α-adrenoceptor
β-adrenoceptor
adrenergic receptor
alpha adrenergic receptor
beta adrenergic receptor
phenoxybenzamine
propranolol
animal experiment
autonomic nervous system
blood and hemopoietic system
drug comparison
drug efficacy
drug mechanism
endocrine system
ganglionectomy
hormone release
hypophysis
nonhuman
preliminary communication
priority journal
rat
subcutaneous drug administration
Animal
Ganglia, Sympathetic
Growth Hormone
Male
Phenoxybenzamine
Pituitary Gland, Anterior
Prolactin
Propranolol
Rats
Rats, Inbred Strains
Receptors, Adrenergic, alpha
Receptors, Adrenergic, beta
Support, Non-U.S. Gov't
Sympathectomy
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00068993_v363_n2_p350_Cardinali
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:Superior cervical ganglionectomy (SCG×) decreased significantly serum growth hormone (GH) levels in rats 14-96 h after surgery, during and immediately after anterograde degeneration of regional sympathetic terminals. At later times (up to 28 days after SCG×) an increase in serum GH was observed. SCG× augments prolactin (PRL) release, but only at the earliest time examined (14 h after surgery). Injection of the α-adrenoceptor blocker, phenoxybenzamine, but not of the β-blocker, propranolol, negated the depression in serum GH found in SCG× rats 14 h after surgery, without affecting PRL release. © 1986.

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