Supramolecular non-amyloid intermediates in the early stages of α-synuclein aggregation

The aggregation of α-synuclein is associated with progression of Parkinson's disease. We have identified submicrometer supramolecular structures that mediate the early stages of the overall mechanism. The sequence of structural transformations between metastable intermediates were captured and...

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Detalles Bibliográficos
Autores principales: Fauerbach, J.A., Yushchenko, D.A., Shahmoradian, S.H., Chiu, W., Jovin, T.M., Jares-Erijman, E.A.
Formato: JOUR
Materias:
alpha synuclein
proton
article
atomic force microscopy
chemical structure
chemistry
cryoelectron microscopy
protein multimerization
protein secondary structure
time
alpha-Synuclein
Cryoelectron Microscopy
Microscopy, Atomic Force
Models, Molecular
Protein Multimerization
Protein Structure, Secondary
Protons
Time Factors
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00063495_v102_n5_p1127_Fauerbach
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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