Effects of a gonadotropin-releasing hormone agonist on rat ovarian follicle apoptosis: Regulation by epidermal growth factor and the expression of Bcl-2-related genes

The purpose of the present study was to evaluate the in vivo effect of the GnRH analogue leuprolide acetate (LA) on follicular development and apoptosis-related mechanisms in preovulatory ovarian follicles (POF) obtained from prepubertal eCG-treated rats. Serum progesterone and estradiol levels were...

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Detalles Bibliográficos
Autores principales: Parborell, F., Pecci, A., Gonzalez, O., Vitale, A., Tesone, M.
Formato: JOUR
Materias:
Apoptosis
Follicle
Gonadotropin-releasing hormone
Growth factors
Ovary
DNA fragment
epidermal growth factor
estradiol
gonadorelin agonist
leuprorelin
progesterone
protein Bax
protein bcl 2
protein bcl xl
chorionic gonadotropin
DNA
gonadorelin
animal cell
apoptosis
article
controlled study
DNA degradation
estradiol blood level
female
gene expression regulation
nonhuman
ovary follicle
ovary follicle atresia
ovary follicle development
priority journal
progesterone blood level
protein stability
rat
animal
biosynthesis
blood
drug effect
drug potentiation
genetics
histology
immunohistochemistry
nick end labeling
physiology
polyacrylamide gel electrophoresis
proto oncogene
Sprague Dawley rat
Western blotting
Animalia
Eukaryota
Fallopia
Animals
Blotting, Western
Chorionic Gonadotropin
DNA Fragmentation
Electrophoresis, Polyacrylamide Gel
Epidermal Growth Factor
Female
Gene Expression Regulation
Genes, bcl-2
Gonadotropin-Releasing Hormone
Immunohistochemistry
In Situ Nick-End Labeling
Leuprolide
Ovarian Follicle
Progesterone
Rats
Rats, Sprague-Dawley
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00063363_v67_n2_p481_Parborell
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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